“病入膏肓”，汉语成语，字面意思是“the disease has spread to the vital organs”，指病到无法医治的地步，也比喻事情到了无可挽回的地步。可以翻译为“be beyond cure/recovery，be incurably ill，be at death's door from illness”等。

例句：

这个病人已病入膏肓，没有多少痊愈的希望了。

The patient has contracted a fatal illness. There is little chance of his recovery.

我不得不说你病入膏肓了。

I have to say you are incurable.