Although I have spoken to him many times, he never took any ________ of what I said.
A.remarkB.attentionC.noticeD.observation在线课程C
解析：
固定搭配。take notice of(vt.)注意到，留心到(通常用于否定句)。如：Take no notice of what others say about your way of life.(别理会别人怎么评价你的生活方式。)
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