As Jane was ill, I was asked to ________ the whole class instead of her.
A.in charge ofB.under the charge ofC.take charge ofD.have a charge of在线课程C
解析：
题意：简病了，所以我被要求代替她来掌管整个班级。take charge of为固定搭配，意为"掌管，控制"。in charge of为介词短语；
under the charge of"在……的控制下"；
D项中多了冠词。